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Home > table of contents > case reports     case reports   neuroimaging findings in gm1 gangliosidosis   dinesh s baviskar, devang j desai, inder talwar, sunila t jaggi   we report neuroimaging findings in an 18-month-old baby who presented with progressive spasticity, delayed milestones, facial dysmorphic features and macrocephaly. viagra no prescription Ct and mri findings with enzyme level correlation, were suggestive of gm1 gangliosidosis   introduction gm1 gangliosidosis is an autosomal recessive lysosomal storage disorder characterized by the generalized accumulation of gm1 ganglioside, oligosaccharides, and the mucopolysaccharide keratan sulphate (and their derivatives). Deficiency of the lysosomal hydrolase, acid b-galactosidase, causes gm1 gangliosidosis and morquio disease type b (i. order generic viagra us E. milkpaint.com/ibe-buy-cheap-viagra-canada-bz/ , mucopolysaccharidosis type iv-b). kamagra generic viagra uk     case report an 18-month-old child presented with history of spasticity, delayed milestones, facial dysmorphic features (depressed nasal bridge) and macrocephaly. sale viagra online canada Retinoscopy revealed macular cherry red spots. Nect scan showed high attenuation involving both thalami, with low attenuation in the cerebral white matter. There was no enhancement on the post contrast study. generic viagra available yet Mri of the brain showed t1 and t2 shortening in the thalami bilaterally. The white matter appeared diffusely hyperintense on t2 weighted images. effects of viagra and women No cerebral atrophy was noted. buy generic viagra online The skeletal survey was normal. Enzyme level estimation was carried out which showed reduced levels of acid b-galactosidase, which is seen in gm1 gangliosidosis.   discussion gm1 gangliosidosis is an autosomal recessive lysosomal storage disorder characterized by the generalized accumulation of gm1 ganglioside, oligosaccharides, and the mucopolysaccharide keratan sulphate (and their derivatives). 1 three clinical subtypes of gm1 gangliosidosis exist, classified by age of onset, as follows: infantile (type 1) : the classic infantile subtype combines the features of a neurolipidosis (i. E. , neurodegeneration, macular cherry-red spots) with those of a mucopolysaccharidosis (i. order generic viagra us E. viagra pills , visceromegaly, osseous dysplasia, dysmorphic facial features). This form of gm1 gangliosidosis most frequently presents in ea. viagra online without prescription order generic viagra us